Lines of Research
1. Great ape genetic variation in the context of human evolution and conservation biology.
Characterizing the variation of thousand of human genomes is standard today. However, primates (our closest relatives) are the ideal set of species to study the evolution of these features from both mechanistic and adaptive points of view.
In this line of research, we use genomic approaches in primate genomes to understand the impact of variants in the evolution of every species to provide a proper perspective to the differences among species.
- Prado-Martinez, Sudmant et al. Nature. 2013
- Hormozdiari et al. Proc Natl Acad Sci U S A. 2013
- Sudmant et al. Genome Res. 2013
- Carbone et al. Nature 2014
- Xue et al. Science. 2015
- Valles-Ibáñez et al. GBE 2016
2. Comparative gene regulation in humans and primates
DNA methylation is an epigenetic modification involved in regulatory processes such as cell differentiation during development, X-chromosome inactivation, genomic imprinting and susceptibility to complex disease. However, the dynamics of DNA methylation changes between human and their closest relatives is still poorly understood. In this project, we evaluate methylation patterns in recent human evolution. We identified a significant positive relationship between the rate of coding variation and alterations of methylation at the promoter level.
- Hernando et al. Plos Genetics 2013
- Heyn et al. Genome Research 2013
- Hernando et al. NAR 2015
- Hernando et al. Plos Genetics 2015 (Review)
3. Canid evolution.
The domestic dog has been widely recognized as an important organism for studying the relationship between selection, genome variation, and phenotypic diversity. Both dogs and wolves have been extensively surveyed using mtDNA, microsatellites, SNPs but structural variation, including variation in multicopy gene families, has not been fully characterized in canines.
- Freedman et al. Plos Genetics 2013
- Ramirez et al. BMC genomics 2014
- Freedman et al. Plos Genetics 2015
- Fan et al. Genome Research 2016
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