Characterizing the variation of thousand of human genomes is standard today. However, primates (our closest relatives) are the ideal set of species to study the evolution of these features from both mechanistic and adaptive points of view.

In this line of research, we use genomic approaches in primate genomes to understand the impact of variants in the evolution of every species to provide a proper perspective to the differences among species.

Related Publications:

• Prado-Martinez, Sudmant et al. Nature. 2013
• Hormozdiari et al. Proc Natl Acad Sci U S A. 2013
• Sudmant et al. Genome Res. 2013
• Carbone et al. Nature 2014
• Xue et al. Science. 2015
• Valles-Ibáñez et al. GBE 2016

DNA methylation is an epigenetic modification involved in regulatory processes such as cell differentiation during development, X-chromosome inactivation, genomic imprinting and susceptibility to complex disease. However, the dynamics of DNA methylation changes between human and their closest relatives is still poorly understood. In this project, we evaluate methylation patterns in recent human evolution. We identified a significant positive relationship between the rate of coding variation and alterations of methylation at the promoter level.

Related Publications:

• Hernando et al. Plos Genetics 2013
• Heyn et al. Genome Research 2013
• Hernando et al. NAR 2015
• Hernando et al. Plos Genetics 2015 (Review)

 Highlights of the paleoproteomics research

Role of Esther

Link to ICP

Related Publications:

• xxx