Functional Genomics and Evolution
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Functional
Genomics
and Evolution

Nutritional
Signals in
Insects lab

PRINCIPAL INVESTIGATOR

José Luis Maestro CSIC Tenured Scientist

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José Luis Maestro - CSIC Tenured Scientist
Nutritional Signals in Insects lab Team
Nutritional Signals in Insects lab

MEMBERS OF THE GROUP (Active in 2018)

Research Technician José Carlos Montañés

Laboratory Technician Viviana Pagone

Graduate Student Carlos Rojano


HIGHLIGHTS OF 2018

Endocrinology of insect vitellogenesis
We identified juvenile hormone acid methyltransferase as a key enzyme in juvenile hormone synthesis in Blattella germanica. In addition, we uncovered differential expression and compensatory transcriptional regulation between different insulin-like peptides.

RNAi pathway
In collaboration with other IBE groups we discovered that the activities of Argonaute-1 (Ago1) and Ago2 in the miRNA and siRNA pathways have been conserved at least from cockroaches to flies, and we demonstrated that Ago2 is responsible for degrading but not for selecting siRNAs.

2018 SELECTED PUBLICATIONS

Rubio, M., Maestro, J.L., Piulachs, M.D. and Bellés, X. (2018). Conserved association of Argonaute 1 and 2 proteins with miRNA and siRNA pathways throughout insect evolution, from cockroaches to flies. Biochimica et Biophysica Acta: Gene Regulatory Mechanisms 1861, 554-590.

Domínguez, C. and Maestro, J.L. (2018). Expression of juvenile hormone acid O-methyltransferase and juvenile hormone synthesis in Blattella germanica. Insect Science 25,787-796.

2018 FUNDED PROJECTS

Title: RNAi “a la carta” para el control de cucarachas.
Funded by: MINECO (Ministry of Science, Spain).
Reference: CGL2016-76011-R.
PI: M.D. Piulachs y J.L. Maestro
Date: 2016-2019
99.000€

Title: Ajuts de suport a la recerca de Catalunya.
Funded by: AGAUR. 2017-2019.
Reference: 2017-SGR 1030
PI: Xavier Bellés
Date: 2017-2019

FIGURE CAPTION

Immunolocalization of BgILP5 in the brain of an adult B. germanica female showing labeled insulin-producing cells (IPCs) in the pars intercerebralis and the three spatial axes. Lower right bottom corner corresponds to the front. The figure is produced by superimposing 50 images using the Zeiss AxioImager Z1 microscope (Apotome) software.