Functional Genomics and Evolution
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Functional
Genomics
and Evolution

Multicellgenome
lab

PRINCIPAL INVESTIGATOR

Iñaki Ruiz Trillo ICREA Research Professor

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Iñaki Ruiz Trillo - ICREA Research Professor
Multicellgenome lab Team
Multicellgenome lab

MEMBERS OF THE GROUP (Active in 2018)

Postdoctoral Researchers Sebastián R. Najle, Andrej Ondracka, Michelle Leger, Omaya Dudin, Dan Richter, David López, Xavier Grau

Predoctoral Researchers Núria Ros, Alicia S. Arroyo, Eduard Ocaña, Alberto Pérez, Konstantina Mitsi, Helena Parra

Research Technicians Aleksandra Kozyczkowska, Maria Ferrer

Laboratory Technician Meritxell Antó

Master student Alfonso Mendaña


HIGHLIGHTS OF 2018

We developed the first genetic tools in a close relative of animals, the filasterean Capsaspora owczarzaki. We also provided a better genome assembly of this organism. This will open future research avenues to address the origin of animals.

We found that animal-type microRNAs and the genes to produce them are not metazoan-specific as previously thought, being present in some unicellular relatives of animals.

We found that the quantity of exon skipping increases significantly in bilaterian animals, compared to other eukaryotes, and is associated to the creation of functional proteins.

2018 SELECTED PUBLICATIONS

Xavier Grau-Bové, Iñaki Ruiz-Trillo and Manuel Irimia (2018).
Origin of exon skipping-rich transcriptomes in animals driven by evolution of gene architecture.
Genome Biology 2018 19:135 (2018)

Andrej Ondracka, Omaya Dudin & Iñaki Ruiz-Trillo (2018)
Decoupling of Nuclear Division Cycles and Cell Size during the Coenocytic Growth of the Ichthyosporean Sphaeroforma arctica. Current Biology. https://doi.org/10.1016/j.cub.2018.04.074

Helena Parra-Acero, Núria Ros-Rocher, Alberto Perez-Posada, Aleksandra Kożyczkowska, Núria Sánchez-Pons, Azusa Nakata, Hiroshi Suga, Sebastián R. Najle, Iñaki Ruiz-Trillo (2018).
Transfection of Capsaspora owczarzaki, a close unicellular relative of animals.
Development, 145 (9). doi: 10.1242/dev.162107

2018 FUNDED PROJECTS

PREMETAZOANEVOLUTION. Unravelling the unicellular prehistory of metazoans by functional analyses and single-cell genomics (ERC-2012-Co, European Research Council)

Origin of Animals: Unravelling the nature of the last unicellular ancestor through a genomic, proteomic and functional approach. (BFU2017-90114-P, MINECO)

New Genetic Tools for Marine Protists (GBMF4973.01, Betty and Gordon Moore Foundation)

SINGEK. Promoting SINgle cell GEnomics to explore the ecology and evolution of hidden microeuKaryotes. (H2020-MSCA-ITN-2015, European Comission)

FIGURE CAPTION

Confocal microscopy images of Capsaspora transfected cells.