Population Genetics
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Population
Genetics

Evolutionary
Population
Genetics lab

PRINCIPAL INVESTIGATOR

Elena Bosch Fusté UPF Associate Professor

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Elena Bosch Fusté - UPF Associate Professor
Evolutionary Population Genetics lab Team
Evolutionary Population Genetics lab

MEMBERS OF THE GROUP (Active in 2018)

Predoctoral Researchers Ana Roca-Umbert, Barbara Sinigaglia, Rocío Caro

Predoctoral Researcher (visiting) Alina Urnikyte


HIGHLIGHTS OF 2018

Exploring adaptation to high altitude: We used genomic data and computational tools to infer demographic events and signatures of positive selection in Native American populations, including two Andean groups.

Exploring adaptation to zinc deficiency: We analysed signatures of classical selective sweeps and polygenic selection in the 24 zinc transporter genes known in humans including populations living in zinc deficient areas.

Inferring adaptive phenotypes: We generated a knock-in mouse for a putative adaptive non-synonymous variant in the Andamanese, which is currently under further analysis.

2018 SELECTED PUBLICATIONS

Flores-Bello A, Mas-Ponte D, Rosu ME, Bosch E, Calafell F, Comas D (2018). Sequence diversity of the Rh blood group system in Basques. Eur J Hum Genet. 26: 1859-1866. https://doi.org/10.1038/s41431-018-0232-1.

De Valles-Ibáñez G, Esteve-Solé A, Piquer M, González-Navarro A, Hernandez-Rodriguez J, Laayouni H, González-Roca E, María Plaza-Martin A, Deyà-Martínez A, Martín-Nalda A, Martínez-Gallo M, García-Prat M, del Pino-Molina L, Cuscó I, Codina-Solà M, Batlle-Masó L, Solís-Moruno M, Marquès-Bonet T, Bosch E, López-Granados E, Aróstegui JI, Soler-Palacín P, Colobran R, Yagüe J, Alsina L, Juan M, Casals F (2018). Evaluating the Genetics of Common Variable Immunodeficiency: Monogenetic Model and Beyond. Frontiers in Immunology 9, Article number: 636. doi:10.3389/fimmu.2018.00636

Buxadé M, Huerga Encabo H, Riera-Borrull M, Quintana-Gallardo L, Lopez-Cotarelo P, Tellechea M, Martinez-Martinez S, Redondo JM, Martin-Caballero J, Flores J, Bosch E, Rodriguez-Fernandez JL, Aramburu J, Lopez-Rodriguez C (2018). Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by NFAT5. J Exp Med. 215(11):2901-2918. https://dx.doi.org/10.1084/jem.20180314

2018 FUNDED PROJECTS

Selección adaptativa en las poblaciones humanas.
(BFU2016-77961-P)”. Funded by Agencia Estatal de Investigación (AEI) , Fondo Europeo de Desarrollo Regional (FEDER), and Ministerio de Economia y Competitividad, Spanish goverment, 2017-2019 (220,000 euros). PIs: Jaume Bertranpetit, Elena Bosch.

Grup de Recerca en Genètica de les Poblacions Humanes (Grup de Recerca Consolidat). Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR), Generalitat de Catalunya, 2017 - 2019 (37,800 euros). PI: Jaume Bertranpetit.

Red temática en Genómica de la Adaptación.
(CGL2017‐90681‐REDT). Acciones de dinamización "Redes de Excelencia". Agencia Estatal de Investigación. Ministerio de Ciencia, Innovación y Universidades. 01/07/2018 – 30/06/2020 (13,000 euros). PI: Fernando Gonzalez-Candelas.

FIGURE CAPTION

Signals of recent selection in the Yanesha (lowland) and Aymara (highland) Peruvian populations.